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The primary enzyme responsible for metabolising nicotine is designated P450 (CYP) 2A6, and studies show genetic differences that cause variations in this enzyme from person to person - and these differences can affect the speed at which nicotine is broken down by up to half

Those who were persistent tobacco smokers reported increasing respiratory symptoms during the study period

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The lead reason why people with bipolar die is smoking-related illnesses. Nicotine is an addictive drug that acts on specific receptors on the brain to cause the release of neurotransmitters, such as serotonin or dopamine